李旭东 Xudong Li
博士，生物材料教授，四川大学 PhD, Professor of Biomaterials, Sichuan University
中国成都望江路29号四川大学生物材料中心（邮编610064）
Room No. 705-3, Biomaterials Building, Sichuan University,
Wangjiang Lu 29#, Chengdu 610064, China
xli20004@yahoo.com
Tel/Fax: +86 28 8541 2102
个人简介Introduction
研究兴趣 Research Interest
主要学术论文 Selected Publications
专利 Patents
茶多酚研究 Research on Tea-Polyphenols
个人简介 Introduction
李旭东于1983年四川大学本科毕业，获理学学士学位（固体物理专业）。1988年起在四川大学分析测试中心开始从事生物材料研究，获硕士学位后留校任职直至副研究员。2000年获英国材料研究所卡耐基奖学金，在英国伦敦大学玛丽皇后材料学院攻读博士学位。2004年作为四川大学引进人才，在国家生物医学材料工程技术研究中心任教授。
Mr Xudong Li got his BSc degree (solid state physics) at Sichuan University in 1983 and then worked as an engineer in Tianjin Synthetic Diamond Company. He began his studies on biomaterials for MSc at Analytical & Testing Center of Sichuan University in 1988, and became an academic staff (assistant/associate researcher) at the university. As awardee of Andrew Carnegie PhD research scholarship (IOM3), Xudong registered in 2000 as a PhD student at the materials department of Queen Mary, University of London. He joined in the National Engineering Research Center for Biomaterials, Sichuan University as full professor of biomaterials in 2004.
研究兴趣 Research Interest
-基于（矿化）胶原、人源角质蛋白和多糖发展用于组织修复与再生的纳米生物材料、复合水凝胶和细胞支架 Nanobiomaterials, composite hydrogels and scaffolds based on (mineralized) collagen, keratin and polysaacharides for tissue repair and regeneration
-材料与细胞的相互作用 Material-cell interactions
-仿生矿化和无机形貌合成（磷酸钙、碳酸钙和草酸钙） Biomimetic mineralization and inorganic morphosynthesis (calcium phosphates, calcium carbonates and calcium oxalates)
-可提升药物/营养物功效的纳米输送体系 Nanoparticulate delivery systems for enhancing the efficacy of guests (drugs/nutrients)
-利用植物多酚(茶多酚)发展新颖生物材料 Novel biomaterials derived from plant polyphenols (Catechins).
主要学术论文 Selected Publications
Guangcan Chen, Zeng Yi, Xiangyu Chen, Xiaomin Ma, Wen Su, and Xudong Li. Polyphenol Nanoparticles from Commonly Consumed Tea for Scavenging Free Radicals, Stabilizing Pickering Emulsions, and Inhibiting Cancer Cells. ACS Applied Nano Materials 2020.
Zhiwen Deng, Zeng Yi, Guangcan Chen, Xiaomin Ma, Ya Tang, Xudong Li. Green tea polyphenol nanoparticle as a novel adsorbent to remove Pb2+ from wastewater. Materials Letters 2021, 284, 128986. IF=3.204
YaqinRan, WenSu, LeiMa, XiaoliangWang, XudongLi. Insight into the effect of sulfonated chitosan on the structure, rheology and fibrillogenesis of collagen, International Journal of Biological Macromolecules 2021, 166, 1480-1490. IF=5.162.
Xiangyu Chen, Zeng Yi, Guangcan Chen, Xiaomin Ma, Wen Su, Zhiwen Deng, Lei Ma, Qiulan Tong, Yaqin Ran and Xudong Li, Carrier-enhanced Photodynamic Cancer Therapy of Self-assembled Green Tea Polyphenol-based Nanoformulations, ACS Sustainable Chemistry & Engineering 2020, 8 (43) , 16372-16384. IF=7.632
Lei Ma, Wen Su, Yaqin Ran, Xiaomin Ma, Zeng Yi, Guangcan Chen, Xiangyu Chen, Zhiwen Deng, Qiulan Tong, Xiaoliang Wang, Xudong Li, Synthesis and characterization of injectable self-healing hydrogels based on oxidized alginate-hybrid-hydroxyapatite nanoparticles and carboxymethyl chitosan, International Journal of Biological Macromolecules 2020, 165, 1164-1174. IF=5.162
Xiaoxiang Ren, Zeng Yi, Zhe Sun, Xiaomin Ma, Guangcan Chen, Zhenhua Chen* and Xudong Li*, Natural polysaccharide-incorporated hydroxyapatite as size changeable, nuclear targeting nanocarriers for efficient cancer therapy, Biomaterials Science 2020, 8(19), 5390-5401. IF=6.183
Wen Su, Yaqin Ran, Lei Ma, Xiaomin Ma, Zeng Yi, Guangcan Chen, Xiangyu Chen, Zhiwen Deng, Qiulan Tong, Xudong Li, Micro-/nano-mechanics dependence of biomimetic matrices upon collagen-based fibrillar aggregation and arrangement, Biomacromolecules 2020, 21(9), 3547-3560. IF=6.082
Zeng Yi, Xiangyu Chen, Guangcan Chen, Zhiwen Deng, Qiulan Tong, Zhe Sun, Xiaomin Ma, Wen Su, Lei Ma, Yaqin Ran, Xudong Li, A General Nanomedicines Platform by Solvent-Mediated Disassembly/Reassembly of Scalable Natural Polyphenol Colloidal Spheres, ACS Appl. Mater. Interfaces 2020, 12 (34), 37914-37928. IF=8.758
Zeng Yi, Guangcan Chen, Xiangyu Chen, Xiaomin Ma, Xinxing Cui, Zhe Sun, Wen Su, and Xudong Li*, Preparation of Strong Antioxidative, Therapeutic Nanoparticles Based on Amino Acids-Induced Ultrafast Assembly of Tea Polyphenols, ACS Appl. Mater. Interfaces 2020, 12(30), 33550-33563. IF=8.758
Zeng Yi, Guangcan Chen, Xiangyu Chen, Zhe Sun, Xiaomin Ma, Wen Su, Zhiwen Deng, Lei Ma, Yaqin Ran, Qiulan Tong, and Xudong Li*, Modular Assembly of Versatile Nanoparticles with Epigallocatechin Gallate, ACS Sustainable Chemistry & Engineering 2020, 8, 9833–9845, featured in ACS Editors’ Choice IF=7.632
Wen Su, Lei Ma, Yaqin Ran, Xiaomin Ma, Zeng Yi, Guangcan Chen, Xiangyu Chen, and Xudong Li*, Alginate-Assisted Mineralization of Collagen by Collagen Reconstitution and Calcium Phosphate Formation, ACS Biomaterials Science & Engineering 2020, 6, 3275-3286. IF=4.152
Xiangyu Chen, Zeng Yi, Guangcan Chen, Xiaomin Ma, Wen Su, Xinxing Cui and Xudong Li, DOX-Assisted Functionalization of Green Tea Polyphenol Nanoparticles for Effective Chemo-Photothermal Cancer Therapy, J. Mater. Chem. B 2019, 7, 4066-4078. IF= 5.047 [pdf]
Xingxing Cui, Songmei Xu, Wen Su, Zhe Sun, Zeng Yi, Xiaomin Ma, Guangcan Chen, Xiangyu Chen, Bo Guo, Xudong Li, Freeze-thaw cyclyes for biocompatible, mechanically robust scaffolds of human hair keratins, J. Biomed. Mater. Res. Part B: Appl. Biomater. 2019, 107B, 1452-1461. IF= 2.674 [pdf]
Zhe Sun, Zeng Yi, Xinxing Cui, Xiangyu Chen, Wen Su, Xiaoxiang Ren, Xudong Li, Tumor-targeted and nitric oxide-generated nanogels of keratin and hyaluronan for enhanced cancer therapy, Nanoscale 2018, 10, 12109-12122. IF= 7.233 [pdf]
Wen Su, Xiaomin Ma, Zhe Sun, Zeng Yi, Xinxing Cui, Guangcan Chen, Xiangyu Chen, Bo Guo, Xudong Li, RhBMP-2 and concomitant rapid material degradation synergistically promote bone repair and regeneration with collagen-hydroxyapatite nanocomposites, J. Mater. Chem. B 2018, 6, 4338-4350. IF= 4.776 [pdf]
Xiaomin Ma, Zhe Sun, Wen Su, Zeng Yi, Xinxing Cui, Bo Guo, Xudong Li, Biologically inspired, catechol-coordinated, hierarchical organization of raspberry-like calcium phosphate nanospheres with high specific surface area, J. Mater. Chem. B 2018, 6, 3811-3819. IF= 4.776 [pdf]
Xiaoxiang Ren, Zhe Sun, Xiaomin Ma, Yanming Wang, Xinxing Cui, Zeng Yi, Xiaoyu Sun, Bo Guo, Xudong Li, Alginate-mediated mineralization for ultrafine hydroxyapatite hybrid nanoparticles, Langmuir 2018, 34, 6797-6805. IF=3.789 [pdf]
Xiaomin Ma, Wanjia Peng, Wen Su, Zeng Yi, Guangcan Chen, Xiangyu Chen, Bo Guo, Xudong Li, Delicate assembly of ultrathin hydroxyapatite nanobelts with nanoneedles directed by dissolved cellulose, Inorg. Chem. 2018, 57, 4516-4523. IF= 4.700 [pdf]
Xiaoyu Sun, Wen Su, Xiaomin Ma, Huaiying Zhang, Zhe Sun, Xudong Li*, Comparison of the osteogenic capability of rat bone mesenchymal stem cells on collagen, collagen/hydroxyapatite, hydroxyapatite and biphasic calcium phosphate, Regenerative Biomaterials 2018, 5, 93-103.
Zeng Yi, Zhe Sun, Guangcan Chen, Huaiying Zhang, Xiaomin Ma, Wen Su, Xinxing Cui, Xudong Li, Size-controlled, colloidally stable and functional nanoparticles based on the molecular assembly of green tea polyphenols and keratins for cancer therapy, J. Mater. Chem. B 2018, 6, 1373-1386. IF= 4.776 [pdf]
Zhe Sun, Zeng Yi, Huaiying Zhang, Xiaomin Ma, Wen Su, Xiaoyu Sun, Xudong Li, Bio-responsive alginate-keratin composite nanogels with enhanced drug loading efficiency for cancer therapy, Carbohyd. Polym. 2017, 175, 159-169. IF=5.158
Huaiying Zhang, Zeng Yi, Zhe Sun, Xiaomin Ma, Xudong Li, Functional nanoparticles of tea polyphenols for doxorubicin delivery in cancer treatment, J. Mater. Chem. B 2017, 5, 7622-7631. IF= 4.776
X. Ma, T. Zhu, Z. Chen, J. Ma, Y. Zhang & X. Li*, Gelatin intervened synthesis of calcite cocoon-like microparticles assembled with small rhombohedra at low temperature, Adv. Appl. Ceram. 2016, 115, 1-5. IF=1.092.
W. Su, X. Ma, X. Sun & X. Li*, Physicochemical characterisation and thermal decomposition of synthetic collagen based nanocomposites in comparison with natural bone, Adv. Appl. Ceram. 2016, 115, 29-35. IF=1.092.
Yanming Wang, Xiaoxiang Ren, Xiaomin Ma, Wen Su, Yaping Zhang, Xiaosong Sun, Xudong Li*, Alginate-Intervened Hydrothermal Synthesis of Hydroxyapatite Nanocrystals with Nanopores, Cryst. Growth & Des. 2015, 15 (4), 1949–1956. IF=3.972.
Libang He, Dongmei Deng, Xuedong Zhou, Lei Cheng, Jacob M. ten Cate, Jiyao Li*, Xudong Li, Wim Crielaard, Novel tea polyphenol-modified calcium phosphate nanoparticle and its remineralization potential, J. Biomed. Mater. Res. Part B: Appl. Biomater. 2015, 103B, 1525–1531. IF=3.373
Zhenhua Chen, Caihong Wang, Junze Chen, Xudong Li*, Biocompatible, functional spheres based on oxidative coupling assembly of green tea polyphenols, J. Am. Chem. Soc. 2013, 135(11), 4179-4182. IF=14.357. [pdf]
Songmei Xu, Lin Sang, Yaping Zhang, Xiaoliang Wang, Xudong Li*, Biological evalution of human hair keratin scaffolds for skin wound repair and regeneration, Mater. Sci. Eng. C 2013, 33, 648-655. IF=5.080.
Zhenhua Chen*, Xiuli Ren, Huihui Zhou, Xudong Li**, The role of hyaluronaic acid in biomineralization, Front. Mater. Sci. 2012, 6(4), 283-296. IF=1.478.
Junze Chen, Zhenhua Chen, Caihong Wang, Xudong Li*, Calcium-assisted hydrothermal carbonization of an alginate for the production of carbon microspheres with unique surface nanopores, Mater. Lett. 2012, 67, 365-368. IF=2.687.
J. F. Ma, S. Q. Wang, R. X. Du, X. D. Li*. Pressureless sintering of gelcast ZTA-MgO-TiO2 systems as potential dental ceramics. Adv. Appl. Ceram. 2011, 110, 275-279. IF=1.092.
Dongmei Luo, Lin Sang, Xiaoliang Wang, Songmei Xu, Xudong Li*. Low temperature, pH-triggered synthesis of collagen-chitosan-hydroxyapatite nanocomposites as potential bone grafting substitutes. Mater. Lett. 2011, 65, 2395-2397. IF=2.687.
Lin Sang, Dongmei Luo, Songmei Xu, Xiaoliang Wang, Xudong Li*. Fabrication and evaluation of biomimetic scaffolds by using collagen-alginate fibrillar gels for potential tissue applications. Mater. Sci. Eng. C. 2011, 31, 262-271. IF=5.080.
Xiaoliang Wang, Lin Sang, Dongmei Luo, Xudong Li*. From collagen-chitosan blends to three-dimensional scaffolds: The influences of chitosan on collagen nanofibrillar structure and mechanical property. Colloids Surf. B: Biointerfaces. 2011, 82, 233-240. IF=3.997.
Zhenhua Chen, Caihong Wang, Huihui Zhou, Xudong Li*. Biomimetic crystallization of toplike calcite single crystals with an extensive (00.1) face in the presence of sodium hyaluronate. Cryst. Growth Des.. 2010, 10, 4722-4727. IF=3.972.
Lin Sang, Xiaoliang Wang, Zhenhua Chen, Jiao Lu, Zhongwei Gu, Xudong Li*. Assembly of collagen fibrillar networks in the presence of alginate. Carbohyd. Polym.. 2010, 82, 1264-1270. IF=5.158.
Lin Sang, Jie Huang, Dongmei Luo, Zhenhua Chen, Xudong Li*. Bone-like nanocomposites based on self-assembled protein-based matrices with Ca2+ capturing capability. J. Mater. Sci. Mater. Med.. 2010, 21, 2561-2568. IF=2.448.
Zhenhua Chen, Huihui Zhou, Xiaoliang Wang, Lin Sang, Caihong Wang, Jianfeng Ma and Xudong Li*. Controlled mineralization by extracellular matrix: monodisperse, colloidally stable calcium phosphate-hyaluronan hybrid nanospheres. Chem. Commun.. 2010, 46, 1278-1280. IF=6.29.
Zhenhua Chen, Caihong Wang, Huihui Zhou, Lin Sang, Xudong Li*. Modulation of calcium oxalate crystallization by commonly consumed green tea. Cryst Eng Comm. 2010, 12, 845-852. IF=3.304. 英国皇家化学会点评期刊《Highlights in Chemical Science》（化学科学亮点）以“绿茶预防肾结石”为题进行了推荐介绍(Green tea prevents kidney stones, Highlights Chem. Sci., 2009, 6, C92)；论文入选Nature China（自然中国）突出研究成果，以“无机化学：绿茶魔力 Inorganic Chemistry: Green Tea Magic”为题对这篇论文进行了研究亮点推荐.
X. M. Wang, X. L. Wang, J. F. Ma, J. M. Jiang, G. Q. Zheng, Z. H. Chen, X. D. Li*. Versatile nanostructured processing strategy for bone grafting nanocomposites based on collagen fibrillogenesis. Adv. Appl. Ceram.. 2009, 108, 384-388. IF=1.092.
Xiaoliang Wang, Xiaomin Wang, Yanfei Tan, Bo Zhang, Zhongwei Gu, Xudong Li*. Synthesis and evaluation of collagen-chitosan-hydroxyapatite nanocomposites for bone grafting. J. Biomed. Mater. Res.. 2009, 89A, 1079-1087. IF=3.231.
Xiaoyan Lin, Xudong Li, Hongsong Fan, Xiantao Wen, Jian Lu and Xingdong Zhang, In situ synthesis of bone-like apatite/collagen nano-composite at low temperature, Materials Letters. 2004, 58(27-28), 3569-3572.
Xudong Li and Mohan J. Edirisinghe, Evolution of the ceramic structure during thermal degradation of a Si-Al-C-O precursor, Chemistry of Materials. 2004, 16(6), 1111-1119.
Xudong Li and Mohan J. Edirisinghe, Structural evaluation of polysilane derived products: from amorphous to thermodynamically stable phases, Philosophical Magazine. 2004, 84(7), 647-671.
Xudong Li and Mohan J. Edirisinghe, A new Al coordination site in Si-C-Al-N-(O) ceramics, Journal of the American Ceramic Society. 2003, 86(12), 2212-2214.
Xudong Li and Mohan J. Edirisinghe, Structural investigation of Si-Al-C-O precursors and their pyrolysis products in nitrogen, Proceedings of the Royal Society A – Mathematical and Physical and Engineering Sciences. 2003, 459(2039), 2731-2747.
Xudong Li and Mohan J. Edirisinghe, Controlled synthesis of silicon carbide-aluminium nitride composites using a preceramic polymer route, Journal of Materials Science Letters. 2002, 21(1), 21-23.
Huichuan Zhao, Xudong Li, Jianxin Wang, Shuxin Qu, Jie Weng and Xingdong Zhang, Characterization of peroxide ions in hydroxyapatite lattice, Journal of Biomedical Materials Research. 2000, 52(1), 157-163.
Xudong Li, Jie Weng, Weidong Tong, Changming Zuo, Xingdong Zhang, Peilu Wang, Zongyang Liu, Characterization of hydroxyapatite film with mixed interface by Ar+ ion beam enhanced deposition, Biomaterials. 1997, 18, 1487-1493.
专利 Patents
李旭东，王晓敏，林晓艳，郑贵球，顾忠伟，张兴栋，有机－无机复合生物材料及其制备方法，专利号ZL200610020802.4（授权公告日：2008-08-06）(胶原纳米人工骨)
李旭东、陈震华、周慧慧、桑琳、王彩虹、顾忠伟、张兴栋，羟基磷灰石纳米复合粒子及其制备方法与应用，专利号ZL200910058587.0（授权公告日：2011-04-27）
李旭东、陈震华、王彩红、周慧慧、桑琳，透明质酸—羟基磷灰石纳米复合球及其制备方法，专利号ZL200910059289.3. （授权公告日：2013-09-11）
李旭东、陈震华、王彩红、陈君泽、周慧慧、桑琳、罗冬梅，黄酮-金属络合微球及其制备方法与应用，专利号 ZL201010207010.4（授权公告日：2013-04-03）
李旭东、王彩红、陈震华、陈君泽、桑琳、罗冬梅，羟基磷灰石杂化纳米晶组装体及其制备方法与应用，专利号ZL201010206973.2（授权公告日：2013-09-25）
李旭东、陈君泽、陈震华、王彩红、彭万佳、周慧慧、马晓敏，羟基磷灰石-多酚复合纳米材料及其制备方法，专利号 ZL201310030097.6（授权公告日：2014-11-26）
李旭东、任肖湘、王彦明、苏文，海藻酸钠-羟基磷灰石杂化纳米粒子及其制备方法，专利号 201510299338.6（授权公告日：2018-01-12）
李旭东、易增、陈光灿、孙哲、马晓敏、苏文、崔新星、陈翔宇，蛋白-多酚复合微球及其制备方法和用途，申请号201711403972.5（申请日期：2017-12-22）